Various protease inhibitors are induced during CNS
autoimmunity. In the CNS, they are mostly secreted by
leukocytes, astrocytes and neurons after inflammatory
stimuli. However, little is known about their effects on CNS
autoimmunity.
SLPI is expressed at mucosal surfaces by epithelial cells,
macrophages and neutrophils. It is involved in the resolution
of inflammation by suppressing protease activity, by
attenuating innate immune responses and by inhibiting the
activation and proliferation of B cells. In the CNS, SLPI
induction has been reported as a consequence of ischemic
stroke, spinal cord injury as well as of autoimmune
conditions. We provided evidence that SLPI is expressed by
astrocytes, microglia and neurons during EAE.
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