Research Programs
Multiple sclerosis -- a chronic, unpredictable nervous system disease -- affects 2.5 million people worldwide, including approximately 400,000 Americans. While it impacts people of virtually all ages, it is the most common disabling disease among young adults between the ages of 20 and 40 years old.
In varying degrees, MS diminishes individuals' ability to speak, walk, write, see, comprehend, concentrate and live productive lives without severe physical limitations. People with MS do not know what symptoms to prepare for or expect, or when or how the disease will affect them.
Research Center programs have expanded the overall body of knowledge concerning the causes and effects of MS. Through their integration into treatment systems and research methods, the Research Center’s findings are continually benefiting MS patients and helping them manage their illness. Key research programs focus on:
Understanding what causes and triggers MS
Certain genes appear to play a role in determining a person’s susceptibility to developing MS. One Research Center program seeks to identify these susceptibility genes and establish their contribution to the disease process.
Another program is investigating two candidate viruses to determine their ability to trigger MS or increase an individual’s risk of developing the disease.
Understanding the mechanisms of disease progression and severity
Because MS is a complex disease and has a variable progression, researchers believe several factors affect its development. Hormonal influences undoubtedly play a role, as is exemplified by the disease’s amelioration during pregnancy and frequent worsening during menopause.
One group of Research Center investigators is exploring hormonal deviations and associated changes in MS among male and female patients.
Another group is studying proteins and inflammatory biomarkers in the cerebrospinal fluid of MS patients to identify markers and triggers that may impact disease severity.
Developing more effective treatments to combat MS and its symptoms
As we gain a better understanding of the mechanisms associated with disease progression and severity, we can develop more effective treatments.
The Research Center played a critical role in introducing intrathecal methotrexate as a treatment to stop the disease from advancing. And it was the first center to effectively use combinations of intrathecal medications to manage both pain and spasticity.
|
